Angiostrongyliasis (Rat Lungworm)
Angiostrongyliasis, also known as rat lungworm, is a disease that affects the brain and spinal cord. It is caused by a parasitic nematode (roundworm parasite) called Angiostrongylus cantonensis. The adult form of A. cantonensis is only found in rodents. However, infected rodents can pass larvae of the worm in their feces. Snails, slugs, and certain other animals (including freshwater shrimp, land crabs, and frogs) can become infected by ingesting this larvae; these are considered intermediate hosts. Humans can become infected with A. cantonensis if they eat (intentionally or otherwise) a raw or undercooked infected intermediate host, thereby ingesting the parasite. For more information on the life-cycle of A. cantonensis, visit the CDC website.
This infection can cause a rare type of meningitis (eosinophilic meningitis). Some infected people don’t have any symptoms or only have mild symptoms; in some other infected people the symptoms can be much more severe. When symptoms are present, they can include severe headache and stiffness of the neck, tingling or painful feelings in the skin or extremities, low-grade fever, nausea, and vomiting. Sometimes, a temporary paralysis of the face may also be present, as well as light sensitivity. The symptoms usually start 1 to 3 weeks after exposure to the parasite, but have been known to range anywhere from 1 day to as long as 6 weeks after exposure. Although it varies from case to case, the symptoms usually last between 2–8 weeks; symptoms have been reported to last for longer periods of time.
You can get angiostrongyliasis by eating food contaminated by the larval stage of A. cantonensis worms. In Hawaii, these larval worms can be found in raw or undercooked snails or slugs. Sometimes people can become infected by eating raw produce that contains a small infected snail or slug, or part of one. It is not known for certain whether the slime left by infected snails and slugs are able to cause infection. Angiostrongyliasis is not spread person-to-person.
Diagnosing angiostrongyliasis can be difficult, as there are no readily available blood tests. In Hawaii, cases can be diagnosed with a polymerase chain reaction (PCR) test, performed by the State Laboratories Division, that detects A. cantonensis DNA in patients’ cerebrospinal fluid (CSF) or other tissue. However, more frequently diagnosis is based on a patient’s exposure history (such as if they have history of travel to areas where the parasite is known to be found or history of ingestion of raw or undercooked snails, slugs, or other animals known to carry the parasite) and their clinical signs and symptoms consistent with angiostrongyliasis as well as laboratory finding of eosinophils (a special type of white blood cell) in their CSF. There is no reliable diagnostic test available to detect previous infections of angiostrongyliasis.
There is no specific treatment for the disease. However, the Governor’s Joint Task Force on Rat Lungworm Disease recently published preliminary evidence-based clinical guidelines for the diagnosis and treatment of neuroangiostrongyliasis. The parasites cannot grow or reproduce in humans and will die eventually, causing inflammation. The preliminary guidelines call for a complete neurologic examination; a detailed history of possible exposure to snails/slugs, rats, or other things suggesting a risk for infection; and a lumbar puncture, or spinal tap, to diagnose the disease and relieve headaches caused by the disease. Steroids should be given as early as possible to reduce inflammation. Anti-parasitic drugs, such as albendazole, may be helpful, although there is limited evidence of this in humans. If albendazole is used, it must be combined with steroids to treat any possible increase in inflammation caused by dying worms. Persons with symptoms should consult their healthcare provider for more information.
Being infected with angiostrongyliasis does not protect you against becoming infected again in the future from another exposure to A. cantonensis.
To prevent angiostrongyliasis, don’t eat raw or undercooked snails or slugs, and if you handle snails or slugs, be sure to wear gloves and wash your hands. Eating raw or undercooked freshwater shrimp, land crabs and frogs may also result in infection, although, there has not been any documented cases in Hawaii. You should also thoroughly inspect and rinse produce, especially leafy greens, in potable water, and boil snails, freshwater prawns, crabs, and frogs for at least 3–5 minutes. Eliminating snails, slugs, and rats founds near houses and gardens might also help reduce risk exposure to A. cantonensis.
Starting in 2017, with an appropriation from the Hawaii State Legislature, DOH launched a public information campaign to educate both residents and visitors about the risks of rat lungworm disease and how to prevent it. Products of the campaign to-date include:
- Mall advertisement (2019) [LINK]
- Airport baggage claim monitors [LINK]
- Television public service announcement 1 [LINK]
- Television public service announcement 2 [LINK]
- Television public service announcement 3 [LINK]
- Radio public service announcement 1 [LINK]
- Radio public service announcement 2 [LINK]
- Radio public service announcement 3 [LINK]
- Informational rack card [LINK]
- Informational door hanger [LINK]
- Informational poster [LINK]
- Mall advertisement [LINK]
- Food Safety banner (horizontal) [LINK]
- Food Safety banner (vertical) [LINK]
Interested persons might check with local medical providers/facilities as to the resources they may offer patients in support of the condition.
Johnston D, Dixon M, Elm J, et al. 2019. Review of Cases of Angiostrongyliasis in Hawaii, 2007–2017. Am J Trop Med Hyg. (Epub ahead of print) View article
Qvarnstrom Y, Xayavong M, da Silva ACA, et al. 2015. Real-Time Polymerase Chain Reaction Detection of Angiostrongylus cantonensis DNA in Cerebrospinal Fluid from Patients with Eosinophilic Meningitis. Am J Trop Med Hyg. (Epub ahead of print) View article
Kwon E, Ferguson TM, Park SY, et al. 2013. A Severe Case of Angiostrongylus Eosinophilic Meningitis with Encephalitis and Neurologi Sequelae in Hawaii. Hawaii J Med Public Health. 72(6): 41–5 View article
Wilkins PP, Qvarnstrom Y, Whelen AC, et al. 2013. The Current Status of Laboratory Diagnosis of Angiostrongylus cantonensis Infections in Humans Using Serologic and Molecular Methods. Hawaii J Med Public Health. 72(6): 55–7 View article
Hochberg NS, Blackburn BG, Park SY, et al, 2011. Eosinophilic Meningitis Attributable to Angiostrongylus cantonensis Infection in Hawaii: Clinical Characteristics and Potential Exposures. Am J Trop Med Hyg. 85(4): 685–90 View article
Hochberg NS, Park SY, Blackburn BG, et al, 2007. Distribution of Eosinophilic Meningitis Cases Attributable to Angiostrongylus cantonensis, Hawaii. Emerg Infect Dis. 13(11): 1675–80 View article
Hollingsworth RG, Kaneta R, Sullivan JJ, et al. 2007. Distribution of Parmarion cf. martensi (Pulmonata: Helicarionidae), a New Semi-Slug Pest on Hawai‘i Island, and Its Potential as a Vector for Human Angiostrongyliasis. Pac Sci. 61(4): 457–67 View article
Qvarnstrom Y, Sullivan JJ, Bishop HS, Hollingsworth R, da Silva AJ. 2007. PCR-Based Detection of Angiostrongylus cantonensis in Tissue and Mucus Secretions from Molluscan Hosts. Appl Environ Microbiol. 73(5): 1415–1419 View article
Preliminary Guidelines for the Diagnosis and Treatment of Human Neuroangiostrongyliasis (Rat Lungworm Disease) in Hawaii
The Clinical Subcommittee of the Hawaii Governor’s Joint Task Force on Rat Lungworm Disease has published its report, “Preliminary Guidelines for the Diagnosis and Treatment of Human Neuroangiostrongyliasis (Rat Lungworm Disease) in Hawaii”. The full document can be read here; below are the key points of the report.
- Clinicians in Hawaii should have a high index of suspicion for neuroangiostrongyliasis.
- Suspect cases should be discussed with the Department of Health (DOH) Disease Investigation Branch (DIB) at the earliest opportunity to facilitate prompt, accurate diagnosis and appropriate patient management. Call (808) 586-4586 for the Disease Reporting Line.
- Typical symptoms in adults include severe headaches, neck stiffness, nausea, paresthesias, and limb pains. Highly suggestive symptoms include migratory hyperesthesias, cranial nerve abnormalities, ataxia, and focal neurologic findings which are migratory or do not follow a dermatomal distribution.
- Typical symptoms in children include fever, abdominal pain, vomiting, irritability, poor appetite, muscle weakness, fatigue, and lethargy.
- Lumbar puncture (LP) is an essential part of the evaluation of suspected neuroangiostrongyliasis. It is a low-risk procedure and has therapeutic benefits, including relief of headaches, nausea, and vomiting.
- A presumptive diagnosis of neuroangiostrongyliasis requires all three of the following:
- A history of suggestive symptoms and signs,
- Evidence of eosinophilic meningitis in the cerebrospinal fluid (CSF), and
- An exposure history, which includes residence in or recent travel to an endemic area.
- Eosinophilic meningitis is the hallmark of the disease and is defined as the presence of 10 or more eosinophils per μL of CSF and/or eosinophils accounting for more than 10% of CSF white blood cells when there are at least 6 total WBC per μL in CSF.
- CSF eosinophil counts may be absent or low early in the course of the disease, requiring repeat LPs if neuroangiostrongyliasis is still suspected.
- Real-time polymerase chain reaction (RTi-PCR) of CSF for A. cantonensis DNA is the best way to confirm the infection and is available in Hawaii through the DIB or from the Centers for Disease Control and Prevention (CDC) for the rest of the United States.
- CSF RTi-PCR may be negative in the early stages of infection.
- Repeat LP and testing is indicated if neuroangiostrongyliasis is still suspected.
- Baseline studies should include a complete blood count (CBC) with differential, serum electrolytes, liver function tests, renal function tests, blood glucose, urinalysis, and chest x-ray.
- Peripheral eosinophil counts of ≥ 500 cells/μL are often present during the course of the illness but may be absent.
- Magnetic resonance imaging (MRI) of the brain, although not required, may be helpful in diagnosing suspected neuroangiostrongyliasis. Focused MRI of the spine may be appropriate if indicated by clinical presentation.
- Serological tests for antibodies against A. cantonensis in the serum or CSF are not recommended for the diagnosis of neuroangiostrongyliasis.
- High dose corticosteroids have been shown to improve clinical outcomes. Start corticosteroids as soon as a presumptive diagnosis of neuroangiostrongyliasis is made and assuming no contraindications.
- Individuals with diabetes or glucose intolerance should be closely monitored.
- Modifications to the patient’s diabetes medications may be needed.
- The addition of albendazole, an anthelminthic drug, may provide additional benefits, although there is limited evidence of this in humans.
- If albendazole is used, combine with corticosteroids to blunt any possible increase in the inflammatory response to dying worms.
- Careful clinical monitoring is recommended in all patients, and specialist consultation (e.g., infectious disease, neurology, etc.) may be advisable.
- Pain management may require early consultation with a pain specialist.
HDOH requires that clinicians report patients with eosinophilic meningitis, i.e., signs and/or symptoms consistent with meningitis plus eosinophils in the cerebrospinal fluid (CSF) without possible alternative causes, including CNS infection with other microbes, reaction to foreign material in the CNS (e.g., intracranial hardware or myelography dye), medications (e.g., intrathecal vancomycin or gentamicin), neoplasms, multiple sclerosis, and neurosarcoidosis by calling (808) 586-4586.
Resources for Clinicians