Dengue

About This Disease

Dengue is a viral illness spread by mosquitoes. All tropical and subtropical region of Asia, Africa, the Caribbean, the Americas, and the Pacific islands are at higher risk for dengue. Nearly all dengue cases reported in the United States were acquired elsewhere by travelers or immigrants. The last reported dengue outbreak was in Hawaii Island in 2015. Most dengue cases in the U.S. citizens occur in Puerto Rico, U.S. Virgin Islands, American Samoa and Guam. There are not yet any vaccines to prevent dengue virus infection, and the most effective protective measure is avoiding mosquito bites.

 

Signs and Symptoms

The symptoms of dengue include sudden onset of fever, severe headaches, eye pain, joint and muscle pain, and rash. The rash typically appears on the hands, arms, legs and feet 3 to 4 days after the fever begins. Minor bleeding of nose or gums or easy bruising may also occur. Sometimes, people with dengue have blood clotting problems. When this happens, the illness is called dengue hemorrhagic fever. Dengue hemorrhagic fever is a very serious illness with abnormal bleeding and very low blood pressure (shock). If not corrected, death can occur.

The symptoms commonly start 4 to 7 days after being bitten by infected mosquitoes, but the onset of symptoms can range from 3 to 14 days. People generally recover within 1 to 2 weeks.

 

Transmission

Dengue is transmitted to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito, which are the same mosquitoes that spread chikungunya and Zika viruses. The mosquito becomes infected when it bites a person who is already infected with the dengue virus. It takes a week or more for the dengue virus to replicate in the mosquito; then the mosquito can transmit the virus to a new person when it bites. Dengue virus cannot be transmitted from person-to-person.

Other modes of transmission that are possible but not as common are through transfusion of infected blood or transplantation of infected organs or tissues; occupational exposure in healthcare setting and infants born to mother acutely ill around the time of delivery.

 

Diagnosis

The diagnosis of dengue is based on a combination of clinical signs and symptoms, travel history, possible exposures, in addition to laboratory testing of the blood, serum, cerebrospinal fluid, other body fluid or tissue. If you have flu-like symptoms and travelled to an area affected by dengue, you should contact your healthcare provider for care and evaluation and stay indoors as much as possible to avoid mosquito bites and help prevent possible spread of the virus.

Treatment

There is no vaccine or specific treatments for dengue. Treatment is supportive. Bed rest and acetaminophen (Tylenol) to treat fever and pain are recommended. Patients are advised to drink fluids to prevent dehydration. Aspirin and non-steroidal anti-inflammatory drugs (like ibuprofen) are not recommended as they can increase the risk of bleeding. If patients are taking medicine for another medical condition, talk to a healthcare provider before taking additional medication.

Immunity

There are four distinct types of dengue viruses (DENV-1, DENV-2, DENV-3, and DENV-4). Infection with one dengue virus type produces lifelong immunity against that specific virus type. A person has a lifetime risk of up to four dengue infections.

Risk in Hawaii

Dengue is not currently circulating in Hawaii; cases of the disease in Hawaii have all been infected through exposures outside of the state. However, Hawaii’s status as a travel destination places it under continual threat of introduction of mosquito-borne diseases. Aedes species mosquitoes competent to transmit those viruses are present in Hawaii. Aedes albopictus is widely spread throughout the state, and Aedes aegypti has been demonstrated in sites on Hawaii Island. Hawaii’s climate creates a year-round mosquito season. Therefore, it is important that individuals with dengue should protect themselves from further mosquito bites during the first week of illness to prevent local transmission of the disease. The Hawaii Department of Health are enhancing the surveillance and prevention of arboviral diseases, and increasing mosquito control efforts. Residents should take basic precautions to protect themselves from mosquitoes by following the Department of Health recommendations.

Prevention

The best way to prevent any mosquito-borne infections is to avoid being bitten by mosquitoes. Some steps you can take to prevent mosquito bites include:

  • Use Environmental Protection Agency (EPA) approved mosquito repellent to exposed skin areas as recommended by product label
  • Wear long pants and long sleeved shirts when outdoors
  • Maintain screen on windows and doors.
  • Empty or drain water at least weekly from garbage cans, house gutters, buckets, pool and boat covers, coolers, toys, flower pots, or any other containers
  • Remove/destroy discarded tires, bottles, cans, pots and pans, and broken appliances

If you are going to be traveling, check before leaving if there is a risk of dengue at your destination, and if so, be sure to take precautions against mosquito bites. For country-specific travel information and recommendations, visit the Centers for Disease Control and Prevention (CDC).

Additional Resources

Information for Clinicians

Dengue is notifiable in Hawaii and should be reported by telephone to the Disease Outbreak Control Division, Disease Investigation Branch on Oahu, or to the District Health Office on the neighbor islands as soon as a provisional diagnosis is established.

Disease Reporting Phone Numbers (24/7)
Oahu (DIB): (808) 586-4586
Maui District Health Office: (808) 984-8213
Kauai District Health Office: (808) 241-3563
Big Island District Health Office (Hilo): (808) 933-0912
Big Island District Health Office (Kona): (808) 322-4877
After hours on Oahu: (808) 566-5049
After hours on neighbor islands: (800) 360-2575 (toll free)

The State Laboratory Division (SLD) of the Hawaii State Department of Health (HDOH) can perform several different tests for dengue. The real-time reverse transcriptase polymerase chain reaction (rRT-PCR) and serologic (immunoglobulin M [IgM]) testing can be done by SLD. Any positive or equivocal IgM result requires follow up testing by plaque-reduction neutralization test (PRNT), currently only available through HDOH at the Centers for Disease Control and Prevention (CDC). All specimens should be routed to SLD through a certified clinical laboratory.

All testing requires HDOH review and approval.  In order to be tested at the SLD, the patient must meet the following criteria:

  1.  Symptomatic* male or female with travel to areas with active Dengue transmission. See CDC Travel Health Notices for current information.

* Men and women who develop signs and/or symptoms consistent with Dengue virus infection within 2 weeks of potential exposures. Symptoms included in the criteria for testing include fever and one or more of the following (headache/retro-orbital pain, nausea/vomiting, myalgia/arthralgia, or generalized maculopapular rash)

 

Asymptomatic men or women do not meet testing criteria and will not be tested for Dengue virus infection by the State of Hawaii Department of Health.

 

Healthcare providers submit the specimens to SLD along with the completed Clinical Specimen Submission Form (SLD Form 81.3). All testing requires HDOH review and approval. If healthcare providers pursue testing through a private commercial lab, consult clinical laboratory for send-out options. Healthcare providers should follow CDC testing criteria for whom to test and guidance for what should be tested.

Other Resources
World Health Organization – Guidelines for diagnosis, treatment, prevention and control

Handbook for clinical management of dengue

Centers for Disease Control and Prevention (CDC) – Dengue Virus Infections Case Definition

Centers for Disease Control and Prevention (CDC) – Clinical and Laboratory Guidance

Clinical Specimen Submission Form (SLD Form 81.3)


SLD Laboratory Test Menu

Dengue PCR

Trioplex

Real-Time RT_PCR